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Zoloft ( sertraline ) can cause insomnia or difficulty sleeping for some people , but tiredness or drowsiness for others. If you experience difficulty sleeping, it might help to take the medication in the morning. As for anxiety , Zoloft is approved to treat social anxiety disorder and is sometimes used off-label to treat generalized anxiety disorder (GAD). Lexapro is approved to treat GAD and can be used off-label to treat social anxiety disorder and panic disorder. Because Zoloft and Xanax are in different drug classes and treat other conditions, studies do not compare the two drugs head to head. Zoloft is generally used as a longer-term treatment, while Xanax is used as a short-term treatment and can potentially abuse and dependence. Taking Zoloft may put you at risk for a rare but possibly life-threatening cond...